Program

Full Abstracts

SUNDAY JULY 14TH

17:00 

Registration opens @ The Rooms

18:00 – 20:00

Welcome Reception @ The Rooms

MONDAY JULY 15TH

SESSION 1: SYNTHETIC BIOLOGY

   
8:30

Molecular MRI in the central nervous system

Alan Jasanoff

Massachusetts Institute of Technology, USA

9:00

Human organic anion transporting polypeptide 1B3 as a trimodality reporter gene using clinical contrast agents

Nyström NN1, Hamilton AM1, Xia W, Liu S2, Scholl TJ1,3, Ronald JA1,4.

1Medical Imaging Laboratories, Robarts Research Institute, London, Ontario; 2Department of Medical Sciences, University of Western Ontario, London, Ontario; 3Ontario Institute for Cancer Research, MaRS Centre, Toronto, Ontario 4Lawson Health Research Institute, London, Ontario, Canada.

9:15

A CRISPR/cas9 homology independent targeted integration (HITI) system for trimodality reporter gene cell tracking

John J. Kelly1,2, Moe Saee-Marand2, Nivin N. Nyström1,2, Yuanxin Chen2, Melissa Evans1, Amanda M. Hamilton2, John A. Ronald1,2.

1Robarts Research Institute and 2Dept. of Medical Biophysics, University of Western Ontario, London, ON, Canada

9:30

A human recombinant contrast agent to measure renal morphology with MRI

Edwin J Baldelomar1,5, Kasey C Emoto4, Neda Parvin5, Maria Veronica Clavijo-Jordan2, Jennifer R Charlton3, Courtnie Yokono4, and Kevin M Bennett4,5

1Physics, University of Hawaii at Manoa, Honolulu, HI, U.S.A., 2 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, U.S.A., 3Pediatrics, University of Virginia, Charlottesville, VA, U.S.A., 4Biology, University of Hawaii at Manoa, Honolulu, HI, U.S.A., 5Washington University in St. Louis, Clayton, MO, U.S.A.

9:45

Engineered protein-iron oxide hybrid biomaterial as magnetic imaging-traceable drug delivery

Kamia Punia1, Lindsay Kathleen Hill1,2,3, James Andrew Tranos3, Zakia Ben Youss3, Teeba Jihad1, Jeff Michael Gaudet4, Xuan Xie1, Erika Delago-Fukushima1, Che Fu Liu1, Jin Kim Montclare1,3,5 and Youssef Zaim Wadghiri3*

1Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA; 2Biomedical Engineering, SUNY Downstate Medical Center, Brooklyn, NY, USA;  3Center for Advanced Imaging Innovation and Research (CAI2R) & Bernard and Irene Schwartz Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY, USA;  4Magnetic Insight, Alameda, CA, USA,  5Chemistry, New York University New York, NY, USA.

10:00 COFFEE BREAK

SESSION 2: NOVEL MECHANISMS OF MR CONTRAST 

10:30

Relaxometry of cancer: effect of water mobility and magnetic field strength on tissue and cell proton T1

Simonetta Geninatti Crich, Maria Rosaria Ruggiero, Simona Baroni, Juan Carlos Cutrin Diego Alberti, Silvio Aime

Department of Molecular Biotechnology and Health Sciences University of Torino, Italy.

11:00

Nano-particle based 19F MRI contrast agent with tunable chemical switches

Kazuki Akazawa1, Masafumi Minoshima1, Fuminori Sugihara2, and Kazuya Kikuchi1,2

1Graduate School of Engineering, Osaka University, Suita, Japan, 2Immunology Frontier Research Center, Osaka University, Suita, Japan 

11:15

Divalent europium-based contrast agents for MRI

S. A. Amali1, S. Subasinghe,1 Jonathan Romero,2 Jason Yustein,3,4 Robia G. Pautler,2 and Matthew J. Allen1

1Department of Chemistry, Wayne State University, Detroit, Michigan, United States, 2Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States, 3Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas, United States, 4Department of Pediatrics, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, United States 

11:30

Development of small Mn-porphyrin based MRI blood pool contrast agents for high field (3T) applications

Hanlin Liu, Piryanka Sasidharan, Vlad Constantinescu, Davesh Chauhan, Ren Ke, and Xiao-An Zhang*

Department of Chemistry, University of Toronto. Department of Physical and Environmental Sciences, Department of Biological Sciences, University of Toronto Scarborough.

11:45

A non-radical quencher broadly suppressing the diaCEST effect

Yen J. Truong1, Mojmir Suchy1,2, and Adam J. Shuhendler1,2,3

1Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2University of Ottawa Heart Institute, Ottawa, Ontario, Canada; 3Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.

12:00 LUNCH 

SESSION 3: ALTERNATIVES TO GADOLINIUM

13:30

MRI detection of enzymatic activities

Eva Toth

Centre of Molecular biophysics, CNRS, Orleans, France

14:00

Iron(III) coordination complexes as MRI contrast agents

Eric M. Snyder, Didar Asik,  Janet R. Morrow

Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States.  Joseph A. Spernyak. Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263. 

14:15

Hydrazocest MRI contrast agents: expanding the toolbox

Mojmír Suchý1,2, Yen Truong 1, Omar Idrissi 1, Zachary J. Comeau 1, and Adam J. Shuhendler 1,2

1Department of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa ON, Canada.2University of Ottawa Heart Institute, Ottawa ON, Canada 

14:30

From excellent research results to a product – the challenge to bring mMRI to patients

Gunnar Schuetz

Bayer AG, Research and Development, Pharmaceuticals, Berlin, Germany

14:45

Advanced nanoassemblies of paramagnetic amphiphilic chelates as MRI contrast agents

Abhishek Gupta1,2, Minoo J. Moghaddam3, Liliana de Campo4, Dj Wijesekera1,2, Mohammad S. Zaman5, and William S. Price1

1 Nanoscale Organisation and Dynamics Group, Western Sydney University, NSW, Australia 2 Ingham Institute of Applied Medical Research, NSW, Australia.3 NanoMed Pty Ltd., NSW, Australia. 4 ANSTO, NSW, Australia.5 School of Science and Health, Western Sydney University, NSW, Australia. 


SESSION 4: MR + X MULTIMODAL IMAGING 1

15:00

Proteins, air and water: biomolecular engineering for magnetic resonance imaging of cellular function

Mikhail G. Shapiro

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA

15:30

Multicore, fast-clearing perfluorocarbon-loaded multimodal nanoparticles for stable ultrasound and 19F MRI applied to in vivo cell tracking

Olga Koshkina1, 2, Guillaume Lajoinie3, Francesca Baldelli Bombelli4, Edyta Swider2, Luis Cruz5, Paul White1, Ralf Schweins7, Yusuf Dolen2, Eric v.Dinther2, Koen v/Riessen2, Sarah Rogers8, Remco Fokkink9, Ilja Voets10, Ernst v/Eck6, Michel Versluis3, Arend Heerschap11, Chris de Korte1, 3, Karin Becker1,  Sebastian Temme11, Oya Tagit1, Andor Veltien1, Uli Flögel11, Carl Figdor2, Jolanda de Vries2, Mangala Srinivas2

1Max-Planck-Institute for Polymer Research, Mainz, Germany. 2Radboud University Medical Center (RUMC), Netherlands 3University of Twente, Netherlands 4Politecnico di Milano, Italy 5Leiden University Medical Centre, Netherlands 7Institut Laue – Langevin, France 8Rutherford Appleton Laboratory, United Kingdom 9Wageningen University, Netherlands 10Eindhoven University of Technology, Netherlands 11Heinrich Heine University, Germany 

15:45

MR-guided ultrasound for directed treatment: results from cabazitaxel in a prostate cancer model

S.M.T. Fagerland1,2, D.K. Hill2, S. Berg2,4,5, S. Snipstad1,3,5, E., Sulheim1,3,5, J. Kim2, C.dL. Davies1

1Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway 3Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway 4Department of Health Research, SINTEF Digital, Trondheim, Norway 5Cancer Clinic, St. Olavs Hospital, Trondheim, Norway 

16:00 – 17:30 POSTER SESSION 1 

TUESDAY JULY 16TH

SESSION 5: MICROENVIRONMENT 1

   
8:30

Molecular MR imaging of glucose stimulated zinc secretion (GSZS) from the mouse prostate

Veronica Clavijo Jordan1,2, Alia Al-Ebraheem3, Tina Geraki4, Andre F. Martins1,5, Sara Chirayil1, Su-Tang Lo1, Christian Preihs1,6, Neil M. Rofsky1, Michael Farquharson3, and A. Dean Sherry1, 5

1Advanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School. 3School of Interdisciplinary Science, McMaster University, Hamilton, Ontario, Canada. 4Diamond Light Source, Harwell, U.K. 5Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA. 6Vitalquan, LLC. Dallas, Texas, USA. 

9:00

MR molecular imaging for detection and active surveillance of prostate cancer

Amita Vaidya, Nadia Ayat, Helen Wang, and Zheng-Rong Lu

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA 

9:15

Molecular magnetic resonance imaging of acute inflammation using a redox active Fe complex

Huan Wang1, M. Veronica Clavijo Jordan1,2, Ian A. Ramsay1, Mozhdeh Sojoodi3, Bryan C. Fuchs3, Kenneth K. Tanabe3, PeterCaravan1,2, Eric M. Gale1

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/ Harvard MedicalSchool. 2Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital. 3Division of Surgical Oncology, Massachusetts General Hospital/ Harvard Medical School.

9:30

Effective MR molecular imaging of aggressive breast cancer with an EDB-FN specific contrast agent at a reduced dose

Nadia R. Ayat, Amita M. Vaidya, Peter L. Qiao, and Zheng-Rong Lu

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States

9:45

Detecting the depletion of liver, splenic, and tumor-associated macrophages with Fluorine-19 MRI at 3 Tesla

Olivia C. Sehl*1,2, Ashley V. Makela1,2, Amanda M. Hamilton1, and Paula J. Foster1,2

1Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada2The Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada

10:00 COFFEE BREAK

 SESSION 6: MICROENVRONMENT 2

10:30

Unraveling cancer biology with multimodal molecular imaging

Kristine Glunde1,2

1The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD. 2The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

11:00

Iopamidol CEST pH and perfusion imaging for monitoring chronic kidney disease

KowsalyaDevi Pavuluri1, Irini Manoli2, Alexandra Pass2, Yuguo Li1,4, Hilary J. Vernon3, Charles P. Venditti 2, and Michael T McMahon*1,4

1The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD. 2Center Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD. 3McKusick-Nathans Institute of Genetic Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD. 

11:15

Developing new targeted molecular contrast agents for imaging inflammation of vulnerable plaque

R. J. Evans1, 2, 3, J. Hernandez-Gil1, Z. Mohri2, K. Y. Chooi2, 5, B. Lavin-Plaza3, A. Phinikaridou3, J. Boyle4, R. Krams5, R. Botnar3, N. J. Long1

1Imperial College London, Department of Chemistry, London, United Kingdom2Imperial College London, Bioengineering, London, United Kingdom3King’s College London, Biomedical Engineering, London, United Kingdom4Imperial College London, NHLI, London, United Kingdom5Queen Mary University of London, Bioengineering, London, United Kingdom 

11:30

Co(II) paraCEST agents for ratiometric pH mapping

Christopher J. Bond 1, Saiful I. Chowdhury 1, Roy Cineus 1, Joseph A. Spernyak 2 and Janet R. Morrow 1

1Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York 14260, United States2Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263.

11:45

Precision diagnostics by noninvasive precision MRI (pMRI)

Jenny J. Yang

Georgia State University, Atlanta, GA, USA 30303, USA

12:00 LUNCH 

SESSION 7: ADVANCED MR IMAGING TECHNIQUES

13:30

Water and molecular imaging: Friends or foes?

Lucio Frydman

Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel

14:00

Simultaneous quantification of iron oxide and gadolinium contrast agent concentration using bSSFP MR fingerprinting

Anna Marriott1,2, Chris Bowen1,2, James Rioux1,2, Kimberly Brewer1,2

1Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS; 2Dalhousie University, Halifax, NS 

14:15

Visualizing salicylate uptake in breast tumors following administration of aspirin using chemical exchange saturation transfer

Kanchan Sonkar1, KowsalyaDevi Pavuluri1, Shaowei Bo1, Caitlin Tressler1, Kristine Glunde1,2, and Michael T. McMahon1,3

1The Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research. 2The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States. 

14:30

Deep learning neural network for CEST magnetic resonance fingerprinting of GBM mouse tumor models

Or Perlman1, Ouri Cohen1, Shuning Huang1, Hirotaka Ito2, Hiroshi Nakashima2, E. Antonio Chiocca2, Matthew S. Rosen1, Christian T. Farrar1

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; 2Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

SESSION 8: MR + X MULTIMODAL IMAGING 1

15:00

Pre-clinical imaging by clinical PET/MRI: multi-modality evaluation in cardiovascular disease from mouse to non-human primates

Claudia Calcagno, M.D., Ph.D

Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai

15:30

Users of electronic cigarettes have increased atherosclerosis as measured by PET/MRI

Anoop Sahota, MD1, Sonum Naidu, BS1, Adam Jacobi, MD1, Mark Woodward, PhD2, Zahi A. Fayad, PhD1, Venkatesh Mani, PhD1

1Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.2The George Institute for Global Health, UNSW, Sydney, Australia. 

15:45

Multi-modality molecular imaging of choline kinase expression in lung cancer

Sofya A Osharovich1, Anatoliy V. Popov1, David E. Holt3, Sunil Singhal2, E. Jim Delikatny1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA2Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA3Perelman School of Medicine and School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA 

16:00 – 17:30 POSTER SESSION 2 
18:30 – 22:30 Dinner and exhibit at Johnson Geo Centre 

WEDNESDAY JULY 17TH

SESSION 9: CELLULAR IMAGING

   
8:30

Visualizing key steps in cancer metastasis using multi-modality in vivo cellular and molecular imaging techniques

Paula Foster1,2

1Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada2The Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada 

9:00

Characterizing the fate of a brain metastatic breast cancer cell line in the severely immune-compromised NSG mouse with MRI

Natasha Knier1,2, Amanda M. Hamilton1, Ashley V. Makela1,2, Paula J. Foster1,2

1Robarts Research Institute, London, Ontario, Canada2Medical Biophysics, Western University, London, Ontario, Canada  

9:15

Multivalent gadolinium-decorated oligopeptides for versatile bioconjugation of molecular MRI probes

Nikorn Pothaye1, Deepak Sail2, Stephen Dodd1, Rolf Swenson2, Alan Koretsky1

1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, United States2Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20814, United States

9:30

Peripheral modifications of manganese porphyrin for extracellular and intracellular MR imaging

Xiao-an Zhang1,2,3

1 Department of Chemistry, University of Toronto,2 Department of Physical & Environmental Science, and 3 Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada 

9:45

Metabolic impacts of CKMT1 over-expression in breast cancer cell lines

Vinay Ayyappan1, Dr. Caitlin Tressler1, Menglin Cheng1, Dr. Kanchan Sonkar1, Ruoqing Cai1, Dr. Michael T. McMahon2, Dr. Kristine Glunde1

1Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

10:00 COFFEE BREAK 

SESSION 10: MOLECULAR MR OF TREATMENT RESPONSE 

10:30

Imaging treatment response

Kevin Brindle1

1Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK

11:00

Imaging liver fibrosis and treatment response in a rat model of nonalcoholic steatohepatitis by multi-parametric MRI

Iris Y. Zhou1, Veronica Clavijo Jordan1, Nicholas Rotile1, Smitha Krishnan2, Gunisha Arora2, Hannah Slattery1, Noah Warner1, Chris Farrar1, Bryan Fuchs2, and Peter Caravan1

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 2Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School. 

11:15

Molecular effects of chemotherapeutic agents on choline phospholipid metabolism of triple negative breast cancer cells

Caitlin M. Tressler1, Menglin Cheng1, Vinay Ayyappan1, Kanchan Sonkar1 and Kristine Glunde1,2

1The Russell H. Morgan Department of Radiology and Radiological Science and 2The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States 

11:30 The Future of Molecular MRI Round Table 
12:30 LUNCH 
14:00 Young Investigator Award Ceremony 
14:15

Keynote Lecture: Bruce Rosen, M.D, Ph.D

Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General Hospital, Harvard Medical School. 

15:15 Adjourn